PYRIMIDINES AS POTENT CYTOTOXIC AND ANTI-INFLAMMATORY AGENTS
نویسندگان
چکیده
منابع مشابه
Boronated Pyrimidines and Purines as Cytotoxic, Hypolipidemic and Anti-Inflammatory Agents
The simple boronated bases, e.g. cytosine, adenine and guanine, containing no sugar residues retained good pharmacological activity as hypolipidemic, anti-neoplastic and anti-inflammatory agents in mice at 8 mg/kg. Their activities were generally identical to their respective nucleoside derivatives. Interestingly the boronated acyclovir derivative was a very potent hypolipidemic agent achieving...
متن کاملDendrimers as anti-inflammatory agents
Pramod Avti is a Postdoctoral Fellow at Montreal Heart Institute, Montreal, Q u e b e c , C a n a d a w o r k i n g o n a collaborative project with Department of Chemistry, McGill University and Ecole Polytechnique, Montreal Canada. His current scientific interests include multifunctional nanomaterials synthesis, and their biomedical applications. In particular, his research is aimed at synthe...
متن کاملFlavonoids as anti-inflammatory agents.
Epidemiological evidence suggests that a high intake of plant foods is associated with lower risk of chronic diseases. However, the mechanism of action and the components involved in this effect have not been identified clearly. In recent years, the scientific community has agreed to focus its attention on a class of secondary metabolites extensively present in a wide range of plant foods: the ...
متن کاملNovel Levofloxacin Derivatives as Potent Antibacterial Agents
In this report, a new series of fluoroquinolone agents which was derived from levofloxacin was synthesized and evaluated against Gram-positive (Bacillus subtillis, Staphylococcus aureus, Staphylococcus epidermidis and Micrococcus luteus) and Gram-negative (Esherichio coli, Klebsiella pneumoniae, Pseudomonas aeruginosa and Serratia marcescens) organisms. The results showed that some of the synth...
متن کاملSinapic Acid Derivatives as Potential Anti-Inflammatory Agents: Synthesis and Biological Evaluation
Transcription factor NF-κB and relevant cytokines IL-6 and IL-8 play a pivotal role in thepathogenesis of inflammation. Sinapic acid is a natural product and was demonstrated to possessanti-inflammatory activity. In this paper, we synthesized a series of sinapic acid derivativesand evaluated their anti-inflammatory effects. The result suggested that all of the targetscompounds 7a-j inhibit NF-κ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Asian Journal of Pharmaceutical and Clinical Research
سال: 2017
ISSN: 2455-3891,0974-2441
DOI: 10.22159/ajpcr.2017.v10i6.17343